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UPB — structural market context

Upstream Bio, Inc.

Structural market context from public regulatory and market data, shown with its as-of dates. Descriptive only: nothing on this page is a recommendation, a prediction, or advice to buy or sell any security.

What changed

As of the close on Oct 21. Each line shows the earlier value, the later value and their dates.

Price

Close $2.80 (Oct 21) vs $2.82 (Oct 20): −0.71%.

Volume

1.26× its 20-session average (1.1M) on Oct 21.

Includes pre- and post-market trading.

Short interest

Short interest 4.5M shares (settlement Sep 30) vs 4.5M (Sep 15).

No new publication in this window. Latest: settlement Sep 30, published Oct 10.

Insider filings (Form 4)

None recorded in this window.

UPB events and their magnitude

Latest SEC filing in the event study

Form 4 · sale · filed 2026-09-17 · View on sec.gov ↗

…

Open the Event Study →

UPB short interest & days to cover

SHARES SHORT
4.5M
% OF FLOAT
22.3%
DAYS TO COVER
7.7
CHANGE VS PRIOR
+0.5%

FINRA consolidated short interest, reported twice a month and published ~2 weeks after each settlement date. % of float uses reported free float. · as of 2026-09-30 (22d ago)

UPB fails-to-deliver (FTD)

Settlement dateFailed sharesPrice
2026-08-31 · 52d704$6.69
2026-08-25 · 58d4K$6.61
2026-08-04 · 79d3K$6.42

SEC fails-to-deliver files, published twice a month with ~6 weeks of delay.

UPB insider buying and selling (Form 4)

Last 12 months, Form 4 codes P and S: 0 purchases · 5 sales

InsiderTypeSharesValueFiled
Deykin Aaron · officer: Chief Medical OfficerSale (S)895$5K2026-09-17
Sutherland Everett Rand · director, officer: Chief Executive OfficerSale (S)2K$12K2026-09-17
GRAY MICHAEL · officer: CFO and COOSale (S)853$5K2026-09-17
Ambrose Allison · officer: General CounselSale (S)485$3K2026-09-17
Houghton Adam · officer: Chief Business OfficerSale (S)700$4K2026-09-17

SEC Form 4 filings: purchases and sales reported on Form 4 (transaction codes P and S) only; grants and option exercises excluded. Attributed public records.

Frequently asked questions

What is UPB's short interest?
As of the FINRA settlement date 2026-09-30, UPB had 4.5M shares sold short — 22.3% of its float, with 7.7 days to cover at average volume. FINRA publishes this data roughly two weeks after each twice-monthly settlement, so it is inherently delayed. A short-interest figure describes an aggregate position; it does not predict what the stock will do.
Are insiders buying UPB?
In the last 12 months of SEC Form 4 filings, UPB recorded 0 insider purchases and 5 sales reported on Form 4 (transaction codes P and S; grants and option exercises excluded). These are attributed public records — information, not instruction.
Is this page telling me to buy or sell UPB?
No. Everything on this page is descriptive, structural market context from public data, shown with its as-of dates. TradeAI News does not issue directional recommendations, price predictions, or buy/sell advice — for any ticker.
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UPB: the full history

Latest rows shown. Full history, market-wide screens, cluster detection and the context journal live in the dashboard.

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Not financial advice. Trading involves risk. Descriptive structural context, never a recommendation.